Hairy Cell Leukemia with Marrow Reactive Plasmacytosis and Mast Cell Hyperplasia: A Case Report and Brief Review of the Literature

Hairy cell leukemia (HCL) and HCL-like disorders, including HCL-variant, are disorders of heterogeneous mature lymphoid B-cells known for their hairy infiltration accompanied by a specific genetic profile, various clinical presentations, and, as they uncommon hematological malignancies characterized pancytopenia, the need appropriate therapy. Sometimes HCL creates diagnostic challenges clinicians, its coincidence or association with mast plasma is rare condition. Herein, we report case confusing manifestations. A 44-year-old man was referred to hospital weakness, fatigue, watery, non-bloody diarrhea. The laboratory tests showed leading referral bone marrow aspiration biopsy. Medium large cells exhibiting widespread cytoplasm, oval nuclei similar monocyte (kidney-shaped) an increased number cells, were observed in biopsy sample. In flow cytometry, neoplastic positive CD19, FMC7, co-expression CD20/CD25, CD11C/CD22, CD103 markers. immunohistochemical staining, CD117, CD138, CD20. Overall, hematopathologists must be aware morphologic confounding factors such lack typical morphological features diagnosis patients HCL.